JENNINGS LAB
SELECTED PUBLICATIONS
For a complete list of peer-reviewed publications, see Laura K. Jennings on Google Scholar.
PNAS
2023
de Mattos CD, Faith DR, Nemudryi AA, Schmidt AK, Bublitz DC, Hammond L, Kinnersley MA, Schwartzkopf CM, Robinson AJ, Joyce A, Michaels LA, Brzozowski RS, Coluccio A, Xing DD, Uchiyama J, Jennings LK, Eswara P, Wiedenheft B, Secor PR. Polyamines and linear DNA mediate bacterial threat assessment of bacteriophage infection. Proc Natl Acad Sci. 2023;120(9):e2216430120.
FRONTIERS IN CELL INFECT MICROBIOL
2022
Secor PR, Michaels LA, Bublitz DC, Jennings LK, Singh PK. The depletion mechanism actuates bacterial aggregation by exopolysaccharides and determines species distribution & composition in bacterial aggregates. Frontiers in Cellular and Infection Microbiology. 2022 Jun 16;797.
MBIO
2022
Schmidt AK, Fitzpatrick AD, Schwartzkopf CM, Faith DR, Jennings LK, Coluccio A, Hunt DJ, Michaels LA, Hargil A, Chen Q, Bollyky PL, Dorward DW, Wachter J, Rosa PA, Maxwell KL, Secor PR. A filamentous bacteriophage protein inhibits type IV pili to prevent superinfection of Pseudomonas aeruginosa. mBio. 2022 Jan 18;:e0244121. doi: 10.1128/mbio.02441-21. [Epub ahead of print] PubMed PMID: 35038902.
NATURE COMMUNICATIONS
2021
Almblad H, Randall TE, Liu F, Leblanc K, Groves RA, Kittichotirat W, Winsor GL, Fournier N, Au E, Groizeleau J, Rich JD, Lou Y, Granton E, Jennings LK, Singletary LA, Winstone TML, Good NM, Bumgarner RE, Hynes MF, Singh M, Stietz MS, Brinkman FSL, Kumar A, Brassinga AKC, Parsek MR, Tseng BS, Lewis IA, Yipp BG, MacCallum JL, Harrison JJ. Bacterial cyclic diguanylate signaling networks sense temperature. Nature Communications. 2021;12(1):1986. doi: 10.1038/s41467-021-22176-2.
CELL REPORTS
2021
Jennings LK, Dreifus JE, Reichhardt C, Storek KM, Secor PR, Wozniak DJ, Hisert KB, Parsek MR. Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies. Cell Reports. 2021;34(8).
FRONTIERS IN IMMUNOLOGY
2020
Secor PR, Burgener EB, Kinnersley M, Jennings LK, Roman-Cruz V, Popescu M, Van Belleghem JD, Haddock N, Copeland C, Michaels LA, de Vries CR, Chen Q, Pourtois J, Wheeler TJ, Milla CE, Bollyky PL. Pf bacteriophage and their impact on Pseudomonas virulence, mammalian immunity, and chronic infections. Frontiers in Immunology. 2020;11:244.
SCIENCE TRANSL MED
2019
Burgener EB, Sweere JM, Bach MS, Secor PR, Haddock N, Jennings LK, Marvig RL, Johansen HK, Rossi E, Cao X, Tian L, Nedelec L, Molin S, Bollyky PL, Milla CE. Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis. Science Translational Medicine. 2019;11(488).
PNAS
2018
Secor PR, Michaels LA, Ratjen A, Jennings LK, Singh PK. 2018. Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa. Proc Natl Acad Sci 28:201806005.
INFECTION AND IMMUNITY
2017
Secor, PR, Michaels, LA, Smigiel, KS, Rohani, MG, Jennings, LK, Hisert, KB, Arrigoni, A, Braun, KR, Birkland, TP, Hallstrand, TS, Lai, Y, Bollyky, PL, Singh, PK, Parks, WC. 2017. Filamentous bacteriophage produced by Pseudomonas aeruginosa alters the inflammatory response and promotes non-invasive infection in vivo. Infection and Immunity 85(1), e00648-16. *Featured on journal cover
SCIENCE ADV
2016
Baker P, Hill PJ, Snarr BD, Alnabelseya N, Pestrak MJ, Lee MJ, Jennings LK, Tam J, Melnyk RA, Parsek MR, Sheppard DC, Wozniak DJ, Howell PL. 2016. Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms. Science Adv 2(5), e1501632.
PNAS
2015
Jennings LK, Storek KM, Ledvina HE, Coulon C, Marmont LS, Sadovskaya I, Secor PR, Tseng BS, Scian M, Filloux A, Wozniak DJ, Howell PL, Parsek MR. 2015. Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix. Proc Natl Acad Sci 112:11353-11358.
MICROBIAL CELL
2015
Secor PR, Jennings LK, Michaels LA, Sweere JM, Singh PK, Parks WC, Bollyky PL. 2015. Biofilm assembly becomes crystal clear–filamentous bacteriophage organize the Pseudomonas aeruginosa biofilm matrix into a liquid crystal. Microbial Cell 3:49-52.
PLOS PATHOGENS
2014
Jones CJ, Newsom D, Kelly B, Irie Y, Jennings LK, Xu B, Limoli DH, Harrison JJ, Parsek MR, White P, Wozniak DJ. 2014. ChIP-seq and RNA-Seq reveal an amrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa. PLoS Pathogens 10:e1003984.
BIODEGRADATION
2013
Field EK, Gerlach R, Viamajala S, Jennings LK, Peyton BM, Apel WA. 2013. Hexavalent chromium reduction by Cellulomonas sp. strain ES6: the influence of carbon source, iron minerals, and electron shuttling compounds. Biodegradation 24:437-450.
BIOAUGMENTATION FOR GROUNDWATER REMEDIATION
Jennings LK, Giddings CG, Gossett JM, Spain JC. 2013. Bioaugmentation for aerobic degradation of cis-1,2-dichloroethene, p 199-217, Bioaugmentation for Groundwater Remediation. Springer, New York.
2013
PLOS ONE
2012
Secor PR*, Jennings LK*, James GA, Kirker KR, Pulcini Ed, McInnerney K, Gerlach R, Livinghouse T, Hilmer JK, Bothner B, Fleckman P, Olerud JE, Stewart PS. 2012. Phevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression. PLoS ONE 7:e40973. *co-first author
GROUNDWATER MONITORING & REMEDIATION
Giddings CG, Jennings LK, Gossett JM. 2010. Microcosm assessment of a DNA probe applied to aerobic degradation of cis-1,2 dichloroethene by Polaromonas sp. strain JS666. Groundwater Monitoring & Remediation 30:97-105.
2010
APPL ENVIRON MICROBIOLOGY
2009
Jennings LK, Chartrand MM, Lacrampe-Couloume G, Lollar BS, Spain JC, Gossett JM. 2009. Proteomic and transcriptomic analyses reveal genes upregulated by cis-dichloroethene in Polaromonas sp. strain JS666. Appl Environ Microbiol 75:3733-3744.